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  • Title: Activity of thyroid parafollicular (C) cells in rats with hyperthyroidism--immunohistochemical investigations.
    Author: Dadan J, Zbucki RL, Sawicki B, Winnicka MM, Puchalski Z.
    Journal: Rocz Akad Med Bialymst; 2004; 49 Suppl 1():135-7. PubMed ID: 15638399.
    Abstract:
    The aim of this study was an evaluation of the activity of parafollicular (C) cells in a rat experimental model of hyperthyroidism, evoked by an intraperitoneal application of L-thyroxine (40 mg/kg daily) over 15 days. For that reason, immunohistochemical investigations and evaluation of calcitonin (CT) plasma concentrations were performed. Differences in the quantity and distribution, together with enhanced CT-immunoreactivity of C cells, were observed in hyperthyroid rats, in comparison to respective values in the control group, accompanied by a significant diminution of plasma TSH and CT levels. Our preliminary study may point to a functional interaction between follicular and parafollicular cells in the thyroid gland.
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