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  • Title: Hypothesis for the pathogenesis of sodium aurothiomalate (Myocrisin) induced immune complex nephritis.
    Author: Skrifvars B.
    Journal: Scand J Rheumatol; 1979; 8(2):113-8. PubMed ID: 156394.
    Abstract:
    Renal complications associated with gold salt treatment in rheumatoid arthritis occur in fewer than 5% of treated patients. Recent investigations have shown that the renal lesion manifested clinically as membranous glomerulonephritis is caused by immune complexes. This paper presents a hypothesis for the mechanism by which gold causes this lesion: autoimmunization due to released tubular antigen(s). This hypothetical mechanism is strikingly similar to that responsible for autologous autoimmune nephrosis in the rat (Heymann's nephritis).
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