These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: In vitro and in vivo effect of fluoxetine on the permeability of 3H-serotonin across rat intestine.
    Author: Martel F, Monteiro R, Lemos C, Vieira-Coelho MA.
    Journal: Can J Physiol Pharmacol; 2004 Nov; 82(11):940-50. PubMed ID: 15644933.
    Abstract:
    The aim of this work was to characterize the mucosal-to-serosal (apical to basolateral; AP-BL) and serosal-to-mucosal (basolateral to apical; BL-AP) transport of serotonin (5-HT) across rat jejunum, ileum, and colon, and to determine the influence of serotonin neuronal transporter inhibitors on this transport. The AP-BL apparent permeability (Papp) of 3H-5-HT increased in the order colon = jejunum < ileum, and the BL-AP Papp of 3H-5-HT increased in the order colon < jejunum = ileum. In vitro, neither fluoxetine (0.02 or 0.2 micromol/L) nor desipramine (0.4 or 4 micromol/L) had a significant effect upon the AP-BL or BL-AP Papp of 3H-5-HT in any of the intestinal regions. However, fluoxetine (0.2 micromol/L) decreased the accumulation of 3H-5-HT in the ileum (to 65% of control) in the BL-AP experiments. In vivo, chronic fluoxetine (10 mg/kg daily administered orally for 15 days), as assessed in the ileum, significantly increased (to +/-180% of control levels) the BL-AP Papp of 3H-5-HT and tended to increase the AP-BL Papp of 3H-5-HT. In conclusion, the increase in the Papp of 3H-5-HT after chronic administration of fluoxetine suggests that this treatment is able to increase the extracellular concentration of 3H-5-HT at the intestinal level.
    [Abstract] [Full Text] [Related] [New Search]