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  • Title: Hydropyrolysis as a preparative method for the compound-specific carbon isotope analysis of fatty acids.
    Author: Sephton MA, Meredith W, Sun CG, Snape CE.
    Journal: Rapid Commun Mass Spectrom; 2005; 19(3):323-5. PubMed ID: 15645412.
    Abstract:
    Compound-specific stable carbon isotope analysis by gas chromatography/combustion/isotope ratio mass spectrometry is an effective and risk-free means of investigating fatty acid metabolism. Straightforward analysis, however, leads to poor chromatographic resolution, while derivatization adds carbon thereby corrupting the starting stable isotopic composition. Hydropyrolysis is a new approach which defunctionalizes fatty acids to yield the corresponding n-alkanes thus retaining the carbon skeleton intact and improving chromatography, allowing the faithful measurement of carbon isotope ratios.
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