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  • Title: Synthesis and pharmacological evaluation of some DL-dichlorophenyl alcohol amides anticonvulsants.
    Author: Meza-Toledo SE, Olea-Gómez A, Mora-Ramírez EY, Peralta-Cruz J, Noguerón-Chirinos JB.
    Journal: Arzneimittelforschung; 2004; 54(12):830-4. PubMed ID: 15646366.
    Abstract:
    The anticonvulsant activity of a homologous series of DL-dichlorophenyl alcohol amides is described. The compounds DL-2-hydroxy-2-(3',4'-dichlorophenyl) butyramide (4, CAS 620950-11-0), DL-3-hydroxy-3-(3',4'-dichlorophenyl) pentanamide (5, CAS 620950-15-4) and DL-4-hydroxy-4-(3',4'-dichlorophenyl) hexanamide (6, CAS 620950-17-6 ) were prepared and tested. Compounds 4, 5 and 6 exhibited a significant activity in seizures induced by pentetrazol. Incorporation of chlorine in the phenyl ring increased their potency. Compound 4 exhibited a slightly lower activity than the reference drug phenobarbital (CAS 50-06-6).
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