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  • Title: Organolithium-mediated diversification of peptide thiazoles.
    Author: Deng S, Taunton J.
    Journal: Org Lett; 2005 Jan 20; 7(2):299-301. PubMed ID: 15646982.
    Abstract:
    [Reaction: see text] We report a one-step, racemization-free method for the diversification of peptide thiazoles via direct lithiation of the thiazole ring. The method is compatible with N-Boc, N-trityl, carboxylic ester, and carboxamide protecting groups and has been used to directly functionalize the thiazole ring of cyclopeptide natural products.
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