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  • Title: Expression of Notch in a case of osteosarcoma of the maxilla.
    Author: Kawakami T, Siar CH, Ng KH, Shimizu T, Okafuji N, Kurihara S, Hasegawa H, Tsujigiwa H, Nagatsuka H, Nagai N.
    Journal: Eur J Med Res; 2004 Nov 29; 9(11):533-5. PubMed ID: 15649865.
    Abstract:
    In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.
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