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  • Title: Bovine herpesvirus 1 VP22 enhances the efficacy of a DNA vaccine in cattle.
    Author: Zheng C, Babiuk LA, van Drunen Littel-van den Hurk S.
    Journal: J Virol; 2005 Feb; 79(3):1948-53. PubMed ID: 15650221.
    Abstract:
    For this study, the intercellular trafficking ability of bovine herpesvirus 1 (BHV-1) VP22 was applied to improve the efficacy of a DNA vaccine in calves. A plasmid encoding a truncated version of glycoprotein D (tgD) fused to VP22 was constructed. The plasmid encoding tgD-VP22 elicited significantly enhanced and more balanced immune responses than those induced by a plasmid encoding tgD. Furthermore, protection against a BHV-1 challenge was obtained in calves immunized with the plasmid encoding tgD-VP22, as shown by significant reductions in viral excretion. However, less significant protection was observed for animals vaccinated with the tgD-expressing plasmid, correlating with the lower level of immunity observed prechallenge. This is the first report of the use of VP22 as a transport molecule in the context of a DNA vaccine for a large animal species.
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