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  • Title: Effects of interferon-beta on the cytokine production of astrocytes.
    Author: Okada K, Kuroda E, Yoshida Y, Yamashita U, Suzumura A, Tsuji S.
    Journal: J Neuroimmunol; 2005 Feb; 159(1-2):48-54. PubMed ID: 15652402.
    Abstract:
    The effects of interferon (IFN)-beta used for treatment of multiple sclerosis (MS) on the central nervous system (CNS) have not yet been elucidated. The effect of IFN-beta and IFN-gamma on astrocytes as the major component of the CNS was investigated using murine primary astrocytes and human astrocytoma U251 cell line. IL-1beta, IL-6, TNF-alpha and iNOS were analyzed by RT-PCR. Both protein and mRNA levels of IL-6 were increased by IFN-beta. IFN-gamma augmented the effect of IFN-beta on IL-6 production. These results suggest that IFN-beta has an activity to modulate inflammatory and immune responses by up-regulating IL-6 in the CNS of MS.
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