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  • Title: Leksell gamma knife radiosurgery for cerebral arteriovenous malformations in pediatric patients.
    Author: Nicolato A, Foroni R, Seghedoni A, Martines V, Lupidi F, Zampieri P, Sandri MF, Ricci U, Mazza C, Beltramello A, Gerosa M, Bricolo A.
    Journal: Childs Nerv Syst; 2005 Apr; 21(4):301-7; discussion 308. PubMed ID: 15654635.
    Abstract:
    OBJECTS: The authors report their experience of gamma knife radiosurgery (GKR) in a large series of pediatric cerebral arteriovenous malformations (cAVMs). The advantages, risks and failures of this approach are presented and discussed. METHODS: Gamma knife radiosurgery was performed on 63 children aged < or =16 years. Haemorrhage was the clinical onset in 50 out of 63 cases. The mean pre-GK cAVM volume was 3.8 cm(3). Fifty-eight out of 63 cAVMs were Spetzler-Martin grades I-III. Most lesions (47 out of 63) were in eloquent or deep-seated brain regions. CONCLUSION: Gamma knife radiosurgery-related complications occurred in 2 out of 47 cases with an available follow-up (1 had transient and 1 permanent morbidity). No bleeding occurred during the latency period. In 39 children with >36-month follow-up, complete cAVM occlusion was angiographically documented in 31, with a 3- and 4-year actuarial obliteration rate of 72 and 77% respectively. High rates of complete obliteration and very low frequency of permanent morbidity with no bleeding during the latency period encourage widespread application of GKR in the treatment of pediatric cAVMs.
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