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  • Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
    Author: Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH.
    Journal: Science; 2005 Jan 21; 307(5708):430-3. PubMed ID: 15662016.
    Abstract:
    Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.
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