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  • Title: Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives.
    Author: Guillon J, Reynolds RC, Leger JM, Guie MA, Massip S, Dallemagne P, Jarry C.
    Journal: J Enzyme Inhib Med Chem; 2004 Dec; 19(6):489-95. PubMed ID: 15662953.
    Abstract:
    New pyrrolo[1,2-a]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25 microg/mL against Mycobacterium tuberculosis H37Rv, with a 94 and 100 percentage inhibition, respectively.
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