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  • Title: Nasal eosinophils correlate with FEV1 in patients with perennial allergic rhinitis associated to asthma.
    Author: Ciprandi G, Milanese M, Tosca MA, Cirillo I, Vizzaccaro A, Ricca V.
    Journal: Eur Ann Allergy Clin Immunol; 2004 Dec; 36(10):363-5. PubMed ID: 15662963.
    Abstract:
    BACKGROUND: Eosinophil inflammation is present in nasal and bronchial mucosa and a clear link between upper and lower airways exists. Our aim was to evaluate whether nasal inflammation correlates with lung function in patients with perennial allergic rhinitis associated with asthma. METHODS: Eighty perennial allergic rhinitics with mild asthma, aged from 18 to 46 years, were enrolled. Nasal scraping and spirometry were performed in all subjects. RESULTS: A close relationship between the nasal eosinophil number and the percentage of predicted FEV1 was demonstrated (r = -0.76; p<0.0001). CONCLUSIONS Nasal cytology may be considered a non-invasive tool to assess airway inflammation in mild asthmatics with associated allergic rhinitis.
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