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  • Title: Genomic medicine, gene polymorphisms, and human biological diversity.
    Author: Balakrishnan VS, Rao M, Jaber BL, DialGene Consortium.
    Journal: Semin Dial; 2005; 18(1):37-40. PubMed ID: 15663763.
    Abstract:
    There is considerable variation in the prevalence of comorbid conditions such as malnutrition, inflammation, cardiovascular disease, and bone disease among end-stage renal disease (ESRD) patients on maintenance hemodialysis. Besides traditional risk factors, these differences also arise from variability in genetic factors and gene-environment interactions. Recent publication of the human genome sequence through the Human Genome and Celera projects has provided a major impetus to the field of molecular genetics and genomic medicine. This review provides a broad overview of recent developments in this field, basic information and terminology in common use, and explores the impact of genetic variations or polymorphisms on human biological diversity.
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