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  • Title: N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
    Author: Batt DG, Houghton GC, Roderick J, Santella JB, Wacker DA, Welch PK, Orlovsky YI, Wadman EA, Trzaskos JM, Davies P, Decicco CP, Carter PH.
    Journal: Bioorg Med Chem Lett; 2005 Feb 01; 15(3):787-91. PubMed ID: 15664858.
    Abstract:
    The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
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