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  • Title: Nucleotide sequence comparison of the M1 genome segment of reovirus type 1 Lang and type 3 Dearing.
    Author: Zou S, Brown EG.
    Journal: Virus Res; 1992 Feb; 22(2):159-64. PubMed ID: 1566600.
    Abstract:
    The mammalian reoviruses possess a genome composed of 10 double stranded RNA segments. The serotype 1 strain Lang M1 segment was sequenced and compared to the published type 3 sequence. Both segments were 2304 base-pairs long coding for the mu 2 protein predicted to be 736 amino acids long. The sequences were highly conserved with 97.2% conservation of nucleotide sequence and 98.6% conservation of amino acid sequence. The M1 segments of serotypes 1 and 3 have recently diverged as indicated by the distribution of variation with respect to codon positions. The conservation of amino acid sequence indicated that the mu 2 protein has a relatively high functional density.
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