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  • Title: The ScaI gene polymorphism of the atrial natriuretic factor and essential arterial hypertension in childhood.
    Author: Zorc-Plesković R, Bidovec M, Bregar D, Milutinović A, Terzić R, Teran N.
    Journal: Coll Antropol; 2004 Dec; 28(2):617-21. PubMed ID: 15666592.
    Abstract:
    In order to investigate the contribution of the atrial natriuretic factor (ANF) gene in pathogenesis of essential arterial hypertension (EAH), we analyzed the ScaI gene polymorphism of the ANF gene in a group of children with EAH. Fifty-eight children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared to 57 subjects with normal blood pressure (the control group). Arterial hypertension was defined as systolic/diastolic blood pressure higher than the 95th age-gender-height percentile of the adopted reference values. We failed to demonstrate an association between the ScaI ANF gene polymorphism and EAH in childhood (OR = 2; 95% CI 0.9-4.2; p = 0.07), however, we provided evidence of an interaction between the ScaI ANF gene polymorphism and obesity defined as BMI over the 85th percentile (OR = 13.1; 95% CI 1.6-106; p < 0.001).
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