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  • Title: Reversal of tacrolimus-related hypertrophic obstructive cardiomyopathy 5 years after kidney transplant in a 6-year-old recipient.
    Author: Jarzembowski TM, John E, Panaro F, Manzelli A, Cabrera A, Greco A, Varga P, Sankary H, Testa G, Benedetti E.
    Journal: Pediatr Transplant; 2005 Feb; 9(1):117-21. PubMed ID: 15667624.
    Abstract:
    Hypertrophic obstructive cardiomyopathy (HOCM) is an unusual but serious side-effect of tacrolimus (TAC) based immunosuppression primarily affecting pediatric patients after solid organ transplant. TAC-induced HOCM has already been described in patients after liver, bowel and heart transplant shortly after the procedure. Herein, we present the first case report of TAC-induced HOCM in a young renal transplant recipient 5 yr after renal transplant. The condition was diagnosed by ECHO and EKG and successfully treated by discontinuation of TAC followed by conversion to cyclosporine (CsA).
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