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  • Title: The HLA locus and multiple sclerosis in Sicily.
    Author: Brassat D, Salemi G, Barcellos LF, McNeill G, Proia P, Hauser SL, Oksenberg JR, Savettieri G.
    Journal: Neurology; 2005 Jan 25; 64(2):361-3. PubMed ID: 15668443.
    Abstract:
    The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients share the HLA-DRB1*1501 susceptibility allele with affected living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.
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