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  • Title: [Clinical features of 35 cases of autoimmune hepatitis-primary biliary cirrhosis overlap syndrome].
    Author: Zeng Z, Han YK, Zhang XF, Geng H.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2005 Jan; 13(1):3-5. PubMed ID: 15670480.
    Abstract:
    OBJECTIVE: To realize the clinical features of autoimmune hepatitis-primary biliary cirrhosis (AIH+PBC) overlap syndrome. METHODS: We analyzed and compared the biochemistry, autoimmune antibodies, and liver biopsy results of 129 autoimmune hepatic disease cases retrospectively, using the international criteria to see which could be diagnosed as AIH/PBC overlap syndrome. RESULTS: Our 35 AIH+PBC overlap syndrome patients were mainly women, with a sex ratio of 1 female: 10 male, and a median age of 50.79+/-11.27 (20 to 70 years old). They had AIH characteristics such as flare of ALT, AST and elevated immunoglobulin G (IgG), gamma-immunoglobulin. There were also antinuclear antibodies (74.3%); moderate or severe periportal or periseptal lymphocytic infiltration, piecemeal necrosis, and florid bile duct lesions, high serum levels of ALP, presence of mitochondrial antibodies (68.6%) and M2 antibodies (45.7%), and features of PBC. CONCLUSIONS: AIH+PBC overlap syndrome is not rare. It should be diagnosed in time and to find effective treatments for it.
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