These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Expression profiling of sciatic nerve in a Charcot-Marie-Tooth disease type 1a mouse model.
    Author: ten Asbroek AL, Verhamme C, van Groenigen M, Wolterman R, de Kok-Nazaruk MM, Baas F.
    Journal: J Neurosci Res; 2005 Mar 15; 79(6):825-35. PubMed ID: 15672449.
    Abstract:
    Expression profiling was performed on sciatic nerve of normal mice and of transgenic mice overexpressing the peripheral myelin protein 22 kDa (PMP22). These mice represent a model for the hereditary peripheral neuropathy Charcot-Marie Tooth type 1A. Comparison of the profiles reveals that the proteasomal degradation pathway and various signaling mechanisms are up-regulated in the diseased nerve. The down-regulated processes represent cell shape and adhesion as well as cellular activity and metabolism. In addition, we found that the most significantly up-regulated differences could not be mapped on known transcripts and thus might represent not identified transcripts. Our data will be helpful to direct future research aimed at deciphering the molecular pathogenesis of the most prevalent hereditary peripheral neuropathy.
    [Abstract] [Full Text] [Related] [New Search]