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  • Title: [A case of advanced rectal cancer responding to 5-fluorouracil based preoperative chemoradiation therapy].
    Author: Ikemoto T, Nishioka M, Ando T, Yawata Y, Terashima Y, Ikushima H, Shimada M.
    Journal: Gan To Kagaku Ryoho; 2005 Jan; 32(1):95-7. PubMed ID: 15675591.
    Abstract:
    We report a case of a 67-year-old female with advanced rectal cancer that showed a significant response after administration of preoperative chemoradiation therapy. 5-fluorouracil (5-FU, 300 mg/m2/day) was administered by 24-hour continuous intravenous infusion after the cancer had been decreased in size by radiation (2 Gy) administered for 20 days preoperatively. Consequently, the patient underwent a low anterior resection with lymph node dissection (D 2), which resulted in a curative resection of the cancer cells macroscopically. Histological examination revealed no residual cancer cells in the resected specimen (CR). Preoperative chemoradiation therapy appears a promising regimen for patients with advanced lower rectal cancer, and can be considered to extend the indication for laparoscopic operations for advanced rectal cancer.
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