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  • Title: Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?
    Author: Joffe RT, Sawka AM, Marriott MJ, MacQueen GM, Gernstein HC.
    Journal: Ann N Y Acad Sci; 2004 Dec; 1032():287-8. PubMed ID: 15677430.
    Abstract:
    Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone.
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