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  • Title: Four new neuroprotective dihydropyranocoumarins from Angelica gigas.
    Author: Kang SY, Lee KY, Sung SH, Kim YC.
    Journal: J Nat Prod; 2005 Jan; 68(1):56-9. PubMed ID: 15679317.
    Abstract:
    Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol (1), 4"-hydroxydecursin (2), (2"S,3"S)-epoxyangeloyldecursinol (3), and (2"R,3"R)-epoxyangeloyldecursinol (4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas, decursinol and decursin, exhibited significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 microM.
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