These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: General anaesthesia does not improve outcome in opioid antagonist detoxification treatment: a randomized controlled trial.
    Author: De Jong CA, Laheij RJ, Krabbe PF.
    Journal: Addiction; 2005 Feb; 100(2):206-15. PubMed ID: 15679750.
    Abstract:
    AIM: Opioid detoxification by administering opioid-antagonists under general anaesthesia has caused considerable controversy. This study is conducted to determine whether rapid detoxification under general anaesthesia results in higher levels of opioid abstinence than rapid detoxification without anaesthesia. DESIGN: Randomized controlled open clinical trial from September 1999 to August 2001. SETTING: Four addiction centres in collaboration with three general hospitals in the Netherlands. PARTICIPANTS: A total of 272 opioid-dependent patients whose previous attempts to abstain were unsuccessful. INTERVENTION: Patients received rapid detoxification with general anaesthesia (RD-GA) or without general anaesthesia (RD). MEASUREMENTS: Urine screens and an interview (EuropASI) to assess opioid abstinence; two questionnaires (SOOS, OOWS) to measure withdrawal symptoms and one to measure craving (VAS). FINDINGS: One month after the intervention 62.8% of the patients in the RD-GA group and 60.0% in the RD group were abstinent for opioids (P = 0.71). No adverse events or complications occurred during RD; however, in the RD-GA group, five adverse events necessitated admission to a general hospital. The average 1-month cost for RD was Euros 2517 versus Euros 4439 for RD-GA. CONCLUSIONS: Rapid detoxification under general anaesthesia did not result in higher levels of opioid abstinence than rapid detoxification without anaesthesia. The cost of the former intervention was much higher.
    [Abstract] [Full Text] [Related] [New Search]