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  • Title: The evolution of synthetic oral drug properties.
    Author: Proudfoot JR.
    Journal: Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1087-90. PubMed ID: 15686918.
    Abstract:
    An analysis of the properties of 1791 synthetic, oral drugs approved and/or marketed since 1937 demonstrates that the median molecular weight of oral drugs has increased substantially over the past 60 years. Fewer than 5% of approved/marketed oral drugs have more than 4-H bond donors and just 2% have MW>500 and >3 H-bond donors.
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