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  • Title: Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
    Author: Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ.
    Journal: Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1173-80. PubMed ID: 15686936.
    Abstract:
    The iterative process for the discovery of a series of pyrazinone mono-amides as potent, selective and reversible non-peptide caspase-3 inhibitors (e.g., M826 and M867) is reported. These compounds display potent anti apoptotic activities in a number of cell based systems in vitro as well as in several animal models in vivo.
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