These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
    Author: Rossman KL, Der CJ, Sondek J.
    Journal: Nat Rev Mol Cell Biol; 2005 Feb; 6(2):167-80. PubMed ID: 15688002.
    Abstract:
    Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate numerous cellular responses such as proliferation, differentiation and movement. With 69 distinct homologues, Dbl-related GEFs represent the largest family of direct activators of Rho GTPases in humans, and they activate Rho GTPases within particular spatio-temporal contexts. The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases.
    [Abstract] [Full Text] [Related] [New Search]