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  • Title: Protein unfolding and refolding under force: methodologies for nanomechanics.
    Author: Samorì B, Zuccheri G, Baschieri R.
    Journal: Chemphyschem; 2005 Jan; 6(1):29-34. PubMed ID: 15688640.
    Abstract:
    An increasing number of inter- and intramolecular interactions can nowadays be probed using single-molecule manipulation techniques. Protein unfolding and refolding is the most representative--though complex--of these interactions. Herein, we review the main modes of performing a force unfolding experiment: the velocity clamp and the new force clamp mode. We also compare some of the physical aspects behind the two most frequently used single-molecule manipulation instrumentations: optical tweezers and atomic force microscopes.
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