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  • Title: Regulation of cap-dependent translation by eIF4E inhibitory proteins.
    Author: Richter JD, Sonenberg N.
    Journal: Nature; 2005 Feb 03; 433(7025):477-80. PubMed ID: 15690031.
    Abstract:
    Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.
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