These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Melanotic schwannoma with drop metastases to the caudal spine and high expression of CD117 (c-kit).
    Author: Tawk RG, Tan D, Mechtler L, Fenstermaker RA.
    Journal: J Neurooncol; 2005 Jan; 71(2):151-6. PubMed ID: 15690131.
    Abstract:
    Melanotic schwannomas (MS) are tumors of Schwann cell origin characterized by cytoplasmic deposition of melanin. The authors present the case of a 61-year-old man who experienced progressive weakness of the lower extremities over 2 years. This was followed by acute deterioration, which prompted his presentation. MRI of the spine revealed an intradural, extramedullary lesion at the level of T7 with severe spinal cord compression. More caudally, there was involvement of the lumbar spine with drop metastases to the conus medullaris and cauda equina. The patient underwent thoracic laminectomy for tumor resection. A diagnosis of MS was made based on histologic morphology, immunohistochemical profile, and ultrastructural findings. In this report, the authors describe a MS with expression of CD117 (c-kit) and review the literature pertaining to this condition.
    [Abstract] [Full Text] [Related] [New Search]