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  • Title: RNA polymerase IV directs silencing of endogenous DNA.
    Author: Herr AJ, Jensen MB, Dalmay T, Baulcombe DC.
    Journal: Science; 2005 Apr 01; 308(5718):118-20. PubMed ID: 15692015.
    Abstract:
    Plants encode subunits for a fourth RNA polymerase (Pol IV) in addition to the well-known DNA-dependent RNA polymerases I, II, and III. By mutation of the two largest subunits (NRPD1a and NRPD2), we show that Pol IV silences certain transposons and repetitive DNA in a short interfering RNA pathway involving RNA-dependent RNA polymerase 2 and Dicer-like 3. The existence of this distinct silencing polymerase may explain the paradoxical involvement of an RNA silencing pathway in maintenance of transcriptional silencing.
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