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  • Title: Pomolic acid triggers mitochondria-dependent apoptotic cell death in leukemia cell line.
    Author: Fernandes J, Weinlich R, Castilho RO, Kaplan MA, Amarante-Mendes GP, Gattass CR.
    Journal: Cancer Lett; 2005 Feb 28; 219(1):49-55. PubMed ID: 15694664.
    Abstract:
    One of the major goals in chemotherapy is to circumvent anti-apoptotic strategies developed by tumor cells. In a previous paper, we showed that pomolic acid (PA) is able to kill the leukemia cell line K562 and its MDR derivative, Lucena 1. Here, we demonstrated that PA-induced apoptosis of HL-60 cells is dependent on the activation of caspases-3 and -9 and dissipation of the mitochondrial transmembrane potential (Deltapsim). Disruption of Deltapsim precedes caspase activation and is not inhibited by zVAD-fmk indicating mitochondria as the main target of PA. Our data pointed to the potential use of PA to overcome apoptosis resistance.
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