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  • Title: Detection of the 47-kilodalton membrane immunogen gene of Treponema pallidum in various tissue sources of patients with syphilis.
    Author: Kouznetsov AV, Weisenseel P, Trommler P, Multhaup S, Prinz JC.
    Journal: Diagn Microbiol Infect Dis; 2005 Feb; 51(2):143-5. PubMed ID: 15698722.
    Abstract:
    Polymerase chain reaction (PCR) was used to detect the 47-kDa immunogen gene of Treponema pallidum in peripheral blood mononuclear cells (PBMCs), skin lesions, and serum, but less consistently in purified granulocytes or ejaculates of patients with manifest and latent syphilis. Therefore, skin lesions and PBMCs may serve as the most reliable sources for a PCR-based diagnosis of syphilis.
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