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  • Title: Virulence attenuation in Salmonella enterica rcsC mutants with constitutive activation of the Rcs system.
    Author: García-Calderón CB, García-Quintanilla M, Casadesús J, Ramos-Morales F.
    Journal: Microbiology (Reading); 2005 Feb; 151(Pt 2):579-588. PubMed ID: 15699206.
    Abstract:
    Mutations in rcsC that result in constitutive colanic acid capsule synthesis were obtained in Salmonella enterica serovar Typhimurium. Most rcsC alleles were dominant; however, recessive rcsC alleles were also found, in agreement with the postulated double role (positive and negative) of RcsC on the activation of the RcsB/C phosphorelay system. Salmonella rcsC mutants with constitutive activation of the Rcs system are severely attenuated for virulence in BALB/c mice and their degree of attenuation correlates with the level of Rcs activation. Partial relief of attenuation by a gmm mutation indicates that capsule overproduction is one of the factors leading to avirulence in constitutively activated rcsC mutants.
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