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  • Title: Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.
    Author: Rathmann S, Rajasalu T, Rosinger S, Schlosser M, Eiermann T, Boehm BO, Durinovic-Belló I.
    Journal: Ann N Y Acad Sci; 2004 Dec; 1037():22-5. PubMed ID: 15699489.
    Abstract:
    In animal models autoreactive CD8(+) T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8(+) T cells contribute to a strong IFNgamma reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development.
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