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Title: Synthesis and schistosomicidal activity of new substituted thioxo-imidazolidine compounds. Author: Albuquerque MC, Silva TG, Pitta MG, Silva AC, Silva PG, Malagueño E, Santana JV, Wanderley AG, Lima MC, Galdino SL, Barbe J, Pitta IR. Journal: Pharmazie; 2005 Jan; 60(1):13-7. PubMed ID: 15700773. Abstract: Synthesis and physico-chemical properties of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-ones, 5-benzylidene-3-(4-nitro-benzyl)-2-thioxo-imidazolidin-4-ones and 4-acridin-9-ylmethylene-1-benzyl-5-thioxo-imidazolidin-2-ones compounds are described. These thioxo-imidazolidine derivatives were prepared by alkylation and condensation with 4-fluoro-benzaldehyde or nucleophilic Michael addition with cyanoacrylates. The schistosomicidal activity of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-one compounds was evaluated.[Abstract] [Full Text] [Related] [New Search]