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  • Title: Studies on the 4-benzoylpyridine-3-carboxamide entity as a fragment model of the Isoniazid-NAD adduct.
    Author: Broussy S, Bernardes-Génisson V, Gornitzka H, Bernadou J, Meunier B.
    Journal: Org Biomol Chem; 2005 Feb 21; 3(4):666-9. PubMed ID: 15703805.
    Abstract:
    An ortho-metallation-electrophilic substitution sequence was employed as a key step to build the 4-benzoylpyridine framework. It was found that 4-benzoylpyridine-3-carboxamide and an N-pyridyl alkylated derivative both exist in a unique cyclized hemiamidal structure, not in the usually expected keto-amide open form. These structures represent fragment models of the Isoniazid-NAD adducts involved in the mechanism of action of the antituberculous drug Isoniazid.
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