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  • Title: [Effects of genistein on the proliferation and lipid peroxidation of rat aortic smooth muscle cells].
    Author: Cui Z, Ge X, Li E.
    Journal: Zhong Yao Cai; 2004 Sep; 27(9):656-8. PubMed ID: 15704585.
    Abstract:
    OBJECTIVE: To investigate the effect of genistein on the proliferation and lipid peroxidation of rat aortic smooth muscle cells (SMC). METHODS: Different concentrations of genistein were used to inhibit the proliferation of smooth muscle cells, and SOD, MDA, cAMP, 6-Keto-PGF1a in medium were observed. MTT method was used to assay the proliferation of SMC. RESULTS: Compared with the control group, 0.1-100 micromol/L genistein could inhibit the proliferation of SMC by increasing SOD activity, raising cAMP and 6-Keto-PGF1a, reducing MDA (P<0.05, P<0.01), and the inhibitory action accompanied with the dose-effect relation.
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