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  • Title: Synthesis and characterization of thiomers of polyaspartamide type.
    Author: Bilicić MB, Filipović-Grcić J, Martinac A, Barbarić M, Zorc B, Cetina-Cizmek B, Tudja P.
    Journal: Int J Pharm; 2005 Mar 03; 291(1-2):211-9. PubMed ID: 15707748.
    Abstract:
    Synthesis of poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-thioglycolic acid (PHEA-TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties.
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