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  • Title: Flavonoids from the leaves of Diospyros kaki reduce hydrogen peroxide-induced injury of NG108-15 cells.
    Author: Bei W, Peng W, Ma Y, Xu A.
    Journal: Life Sci; 2005 Mar 11; 76(17):1975-88. PubMed ID: 15707880.
    Abstract:
    Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)-induced apoptosis-like damage of NG108-15 cells. Pretreatment of cells with FLDK-P70 alleviated H2O2-induced cell injury and apoptosis by upregulating Bcl-2 expression and improving redox imbalance as indicated by the alleviation of the decline in the intracellular endogenous antioxidants: glutathione and glutathione peroxidase as well as catalase, with the decrease of the leak of lactate dehydrogenase and the reduction of the accumulation of malondialdehyde. These results indicate that FLDK-P70 may be potentially used in the prevention and treatment of ischemia/reperfusion injury and other neurodegenerative disease. Upregulating bcl-2 and improving cellular redox state by FLDK-P70 may play critical roles in attenuating oxidative injury.
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