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  • Title: Dephosphorylation of eNOS on Thr495 after transient forebrain ischemia in gerbil hippocampus.
    Author: Hashiguchi A, Yano S, Morioka M, Hamada J, Kochi M, Fukunaga K.
    Journal: Brain Res Mol Brain Res; 2005 Feb 18; 133(2):317-9. PubMed ID: 15710249.
    Abstract:
    We investigated phosphorylation of endothelial nitric oxide synthase (eNOS) at two major sites, Ser1177 and Thr495, which has a critical role to control its activity, in the gerbil hippocampal microvasculature after transient forebrain ischemia. Ser1177 phosphorylation was unchanged by 24 h after reperfusion, despite post-ischemic up-regulation of eNOS protein. However, Thr495 phosphorylation significantly and persistently decreased by 48 h. We here defined the changes in eNOS phosphorylation in vivo following brain ischemia/reperfusion. (ischemia).
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