These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1.
    Author: Chau KY, Keane-Myers AM, Fedele M, Ikeda Y, Creusot RJ, Menozzi L, Cousins DJ, Manfioletti G, Feigenbaum L, Fusco A, Ono SJ.
    Journal: Int Immunol; 2005 Mar; 17(3):297-306. PubMed ID: 15710911.
    Abstract:
    We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome formation. This finding is supported by our direct studies of T cells isolated from the HMGA1-transgenic mice displaying an up-regulation of IFN-gamma production and of HMGA1-deficient mice exhibited a decreased IFN-gamma induction. In parallel transfection studies in EL4 cells, we observed elevated IFNG gene promoter activity in cells stably over-expressing HMGA1 and a reduction of such activity in cells expressing dominant-negative HMGA1. In vitro binding assays further demonstrated a specific interaction of HMGA1 to defined regions of the IFNG gene proximal promoter.
    [Abstract] [Full Text] [Related] [New Search]