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  • Title: Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors.
    Author: Ahn JH, Kim JA, Kim HM, Kwon HM, Huh SC, Rhee SD, Kim KR, Yang SD, Park SD, Lee JM, Kim SS, Cheon HG.
    Journal: Bioorg Med Chem Lett; 2005 Mar 01; 15(5):1337-40. PubMed ID: 15713382.
    Abstract:
    A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 microM and ED50 value of 80 mg/kg (in vivo DP-IV inhibition; po).
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