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  • Title: [Influence of growth rates of local recurrences and in-transit metastases on survival of patients with cutaneous melanoma].
    Author: Mikhnin AE, Barchuk AS, Wagner RI, Anisimov VV.
    Journal: Vopr Onkol; 2004; 50(5):557-61. PubMed ID: 15715096.
    Abstract:
    The growth rates of local recurrences and in-transit metastases of skin melanoma were assessed in 271 patients. Median growth rate in the course of chemotherapy was 0.02 a day--1 which corresponded to a doubling time of 34.7 days. Median survival time for patients with local recurrences and in-transit metastases was 22.6 months, 12-month survival--70.1%, 5-year--19.6% and 10-year--9.9%. Growth rate appeared to be the most significant prognostic factor; similarly important were tumor volume, relapse-free interval, tumor mitotic rate, site and number of recurrences. The following additional characteristics of tumor growth rate have been suggested: maximum growth rate and doubling time limit, to assess the rates of secondary tumor focus development.
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