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  • Title: Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.
    Author: Cook B, Hoogenboom G.
    Journal: Australas Psychiatry; 2004 Mar; 12(1):74-6. PubMed ID: 15715745.
    Abstract:
    OBJECTIVE: To report on a trial of adding amisulpride to clozapine. METHODS: Description of six cases. RESULTS: Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms. CONCLUSION: The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.
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