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  • Title: Hepatitis delta superinfection during alpha-interferon treatment for hepatitis B.
    Author: Craxì A, Di Marco V, Bruno R, Fabiano C.
    Journal: Ital J Gastroenterol; 1992 Jan; 24(1):19-20; discussion 20-1. PubMed ID: 1571575.
    Abstract:
    Alpha-interferon (IFN) has been used to treat hepatitis B virus carriers with chronic hepatitis Delta virus superinfection. Although the drug inhibits hepatitis Delta virus replication during administration, long-term clearance of the virus has not been obtained in most patients. The effectiveness of alpha-interferon on chronic HDV infection is therefore questionable. No data are available on acute infection. We report the case of a young, immunocompetent HBsAg carrier in whom hepatitis Delta virus superinfection occurred while he was receiving alpha-interferon in order to reduce high level HBV replication, and followed a peculiar course.
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