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  • Title: Transient changes in cortical glucose and lactate levels associated with peri-infarct depolarisations, studied with rapid-sampling microdialysis.
    Author: Hopwood SE, Parkin MC, Bezzina EL, Boutelle MG, Strong AJ.
    Journal: J Cereb Blood Flow Metab; 2005 Mar; 25(3):391-401. PubMed ID: 15716860.
    Abstract:
    Peri-infarct depolarisations (PIDs) contribute to infarct expansion in experimental focal ischaemia; furthermore, depolarisations propagate in the injured human brain. Glucose utilisation is increased under both conditions, and depletion of brain glucose carries a poor prognosis. We studied dynamics of cerebral glucose and lactate in relation to PID patterns in experimental stroke. The middle cerebral artery was occluded for 3 h in 23 cats under terminal chloralose anaesthesia. We used fluorescence imaging to detect occurrence of PIDs, and rapid-sampling online microdialysis (rsMD), coupled to a flow-injection assay, to examine changes in cerebral cortical extracellular glucose and lactate at intervals of 30 sec each. After 30 min' ischaemia, lactate had increased by 43.6+/-s.d. 45.9 micromol/L, and stabilised in that range for 3 h. In contrast, glucose fell only slightly initially (11.9+/-9.7 micromol/L), but progressively decreased to a reduction of 56.7+/-47.2 micromol/L at 3 h, with no evidence of stabilisation. There was a highly significant inverse relationship of frequency of PIDs with plasma glucose (P<0.001). The results also characterise a metabolic signature for PIDs for possible application in clinical work, and emphasise potential risks in the use of insulin to control plasma glucose in patients with brain injury.
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