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  • Title: Infantile systemic lupus erythematosus presenting with pulmonary hemorrhage.
    Author: Kreindler J, Ellis D, Vats A, Kurland G, Ranganathan S, Moritz ML.
    Journal: Pediatr Nephrol; 2005 Apr; 20(4):522-5. PubMed ID: 15717168.
    Abstract:
    Systemic lupus erythematosus in infants born to healthy mothers is a rare entity. We describe a male infant who presented at 1 month of age with pulmonary hemorrhage and glomerulonephritis due to systemic lupus erythematosus, confirmed serologically and histologically. He was managed with a combination of prednisone and intermittent cyclophosphamide, but also received mycophenolate mofetil, with a complete serological and clinical remission at 30-month follow-up. This case underscores the importance of a broad approach to the evaluation of pulmonary hemorrhage and glomerulonephritis in the very young and the need for aggressive immunosuppressive therapy to achieve sustained serological and clinical remission.
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