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  • Title: Multivariate linear discrimination of seizures.
    Author: Jerger KK, Weinstein SL, Sauer T, Schiff SJ.
    Journal: Clin Neurophysiol; 2005 Mar; 116(3):545-51. PubMed ID: 15721068.
    Abstract:
    OBJECTIVE: To discriminate seizures from interictal dynamics based on multivariate synchrony measures, and to identify dynamics of a pre-seizure state. METHODS: A linear discriminator was constructed from two different measures of synchronization: cross-correlation and phase synchronization. We applied this discriminator to a sequence of seizures recorded from the intracranial EEG of a patient monitored over 6 days. RESULTS: Surprisingly, we found that this bivariate measure of synchronization was not a reliable seizure discriminator for 7 of 9 seizures. Furthermore, the method did not appear to reliably detect a pre-seizure state. An association between anti-convulsant dosage, frequency of clinical seizures, and discriminator performance was noted. CONCLUSIONS: Using a bivariate measure of synchronization failed to reliably differentiate seizures from non-seizure periods in these data, nor did such methods show reliable detection of a synchronous pre-seizure state. The non-stationary variables of decreasing antiepileptic medication (without available serum concentration measurements), and concomitant increasing seizure frequency contributed to the difficulties in validating a seizure prediction tool on such data. SIGNIFICANCE: The finding that these seizures were not a simple reflection of increasing synchronization in the EEG has important implications. The non-stationary characteristics of human post-implantation intracranial EEG is an inherent limitation of pre-resection data sets.
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